Enhancing Memory Function and Cognitive Flexibility

A proven pharmaceutical team developing innovative treatments for psychiatric and neurological disorders.

Psynergy Pharmaceuticals is currently focused on treating autism spectrum disorders.

Over 30 years of experience in drug development research and working with the pharmaceutical industry

Listen to the team discuss the I-Corps@Ohio experience from the summer of 2018.

Our Team

William Messer

William S. Messer, Jr., Ph.D.
President and Chief Scientific Officer

Austin Horton

Austin Horton
Lead Scientist

Research

Linking muscarinic receptor activation to UPS-mediated object memory destabilization: Implications for long-term memory modification and storage.

Abstract Consolidated memories can become destabilized during reactivation, resulting in a transient state of instability, a process that has been hypothesized to underlie long-term memory updating. Consistent with this notion, relatively remote memories, which are resistant to standard destabilization procedures, are reliably destabilized when novel information (i.e., the opportunity for memory updating) is present during […]

Evaluation of 1,2,5-thiadiazoles as modulators of M1/M5 muscarinic receptor subtypes.

Abstract Studies have demonstrated the presence of allosteric binding sites on each of the muscarinic acetylcholine receptor (mAChR) subtypes. Since most drugs targeting muscarinic receptors bind to the highly conserved orthosteric binding site, they fail to achieve appreciable subtype selectivity. Targeting non-conserved allosteric sites may provide a new way of enhancing selectivity for individual subtypes […]

The selective M1 muscarinic cholinergic agonist CDD-0102A enhances working memory and cognitive flexibility.

Abstract Various neurodegenerative diseases and psychiatric disorders are marked by alterations in brain cholinergic function and cognitive deficits. Efforts to alleviate such deficits have been limited by a lack of selective M(1) muscarinic agonists. 5-(3-Ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine hydrochloride (CDD-0102A) is a partial agonist at M(1) muscarinic receptors with limited activity at other muscarinic receptor subtypes. The present […]

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